Ubiquitin System
نویسندگان
چکیده
منابع مشابه
The ubiquitin-proteasome-system.
NOTICE: this is the author’s version of a work that was accepted for publication in Biochimica et Biophysica Acta Molecular Cell Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for pu...
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Ubiquitination determines the longevity of proteins in cells and plays major roles in signaling. The complexity of the ubiquitination proteasome system (UPS) is evident in the number of enzymes that are involved, including hundreds of ligases and roughly a hundred deubiquitinases (DUBs) that add or remove ubiquitin chains, respectively. Furthermore, ubiquitin modifications on proteins are recog...
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In eukaryotes, thousands of genes have to be organized and expressed in the cell nucleus. Conformational and kinetic instability of nuclear structure and components appear to enable cells to use the encoded information selectively. The ubiquitin-proteasome system is active in distinct nuclear domains and plays a major role controlling the initial steps of gene expression, DNA repair and nuclear...
متن کاملUbiquitin in the immune system
Ubiquitination is a post-translational modification process that has been implicated in the regulation of innate and adaptive immune responses. There is increasing evidence that both ubiquitination and its reversal, deubiquitination, play crucial roles not only during the development of the immune system but also in the orchestration of an immune response by ensuring the proper functioning of t...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2018
ISSN: 1422-0067
DOI: 10.3390/ijms19041080